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Results from a clinical be educated conduct contained by 1,229 patients next to posture II diabetes mellitus and lofty cholesterol make clear that VYTORIN® (ezetimibe/simvastatin) provide person over you tightening in LDL “bad” cholesterol finger to Lipitor® (atorvastatin) at the dose comparison studied, according to information published in the December 2006 dynamic of Mayo Clinic Proceedings. The pilot efficacy endpoint be the percent money from baseline in LDL cholesterol at the expiration of the six-week managing spell.

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VYTORIN 10/20 mg demonstrated a 53.6 anticipate percent reduction from baseline in LDL cholesterol as compared to a 38.3 percent reduction observed with Lipitor 10 mg and a 44.6 percent reduction with Lipitor 20 mg - the recommended majority starting dose of both agents. At the subsequent utmost doses, VYTORIN 10/40 mg decrease LDL cholesterol importantly sophisticated than Lipitor 40 mg - 57.6 percent compared to 50.9 percent, respectively, (p<0.001 all for all three comparisons).

“Patients with diabetes and high cholesterol be considered to be in the high venture category for heart virus, according to the National Cholesterol Education Program (NCEP) Adult Treatment Panel III (ATP III),” said Theodore Mazzone, M.D., professor, Departments of Medicine and Pharmacology, chief, Section of Endocrinology, Diabetes and Metabolism, University of Illinois, Chicago. “This study showed that VYTORIN was significantly more successful than Lipitor in reducing LDL “bad” cholesterol when compare the recommended usual starting doses and the next highest doses.” In this study, the greater LDL cholesterol reduction with VYTORIN 10/20 mg help more patients with type 2 diabetes (90.3 percent) snatch unpromising the LDL cholesterol treatment purpose (<100 mg/dL) prearranged by the NCEP ATP III guidelines versus patients taking Lipitor 10 mg (70.0 percent; p<0.001) and Lipitor 20 mg (82.1 percent; p=0.007). VYTORIN 10/40 mg versus Lipitor 40 mg resulted in 93.4 percent and 88.8 percent of patients, respectively, reaching a LDL cholesterol goal of <100 mg/dL (p=.07,NS).

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